Introduction

Gut microbiota promote human gastrointestinal health, and the disruptionof gut microbiota is related to the occurrence and development of manydiseases. Supplementing probiotics is a commonly method for altering thegut microbiota to improve health. However, there is no clear literature onthe impact of probiotics on the gut microbiota of healthy adults.

Therefore,based on preclinical studies such as previous animal experiments, weevaluated the impact ofLacticaseibacillus rhamnosusLRa05on the gutmicrobiota of healthy adults, including gastrointestinal tolerance, safety,and intestinal colonization, to clarify the impact of LRa05 on the gutmicrobiota.

Study Design

A randomized, double-blind, placebo-controlled trial was conducted amongparticipants who were randomly divided into a placebo (maltodextrin group) anda probiotic LRa05 intervention group (10B CUF/d) for 4 weeks. Using 16S rRNAhigh-throughput sequencing to study the changes of gut microbiota

Key Findings

✓LRa05 significantly increases the abundance of intestinalLactobacillus in healthy adults

✓LRa05 has the potential of gastrointestinal tolerance andcolonization, and regulates the gut microbiota, reduced thepotential for pathogenic bacteria such as Salmonella

Future Direction

✓Validation and expansion of preclinical studies based on theearly LRa05 animal experiments

✓Explore the effects of LRa05 on gut health in a wider population

✓Clinical evidence-based dosage, safety, and indications of LRa05candidate drugs